ArcGIS online: Is something similar to this possible to create?

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is it possible to create a map like that one on the picture in ArcGIS online?

important criteria:

• label and points need to be connected with a line
  
• labels should have a bold headline
  
• the Map should automatically update edits in the excel file (.xls oder .xlsx)
  
• last: particular own georeferenced maps should be added
  

Currently, I'm working with QGIS, where bullet points 2,3 are not possible and bullet point 2 not as I wish (an extra layer is needed)I appreciate your help! Thank you!



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